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Single-use Dissolved Oxygen Sensors
Accurate DO Measurement in Single-use Bioreactor Bags
Single-use oxygen sensors utilize optical spot technology for measuring dissolved oxygen in bioprocessing applications that use single-use bags. METTLER TOLEDO single-use DO sensors are designed to be integrated securely into single-use bags by the bag manufacturer. With their robust design for optimal process safety, these single-use DO sensors ensure long-term stability for use throughout an entire batch process, while offering an output signal identical to a reusable sensor.
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Reliable Dissolved Oxygen Measurement
These single-use DO sensors use optical spot technology, also called fluorescence quenching technology, to give consistent and reliable oxygen measurements in bioprocessing applications.
Ensures Stable Performance over Long Batches
These single-use optical DO sensors provide stable performance during long cell culture runs, ensuring the sensor will last through the entire batch.
Suitable for Use in a Wide Range of Applications
METTLER TOLEDO single-use oxygen sensors can be used throughout a broad range of harsh applications, including cell culture, harvesting and fermentation.
Ensure Fast Commissioning of New Bags
The short pre-conditioning phase of METTLER TOLEDO single-use optical oxygen sensors ensures a quick start up time.
Rugged Materials for Established Process Safety
All wetted polymer materials used on single-use DO sensors are made of USP 88 VI certified materials to ensure the highest process safety to meet your biocompatibility requirements.
Unique Design Ideal for Welding to Bag Stock
Single-use pH sensors from METTLER TOLEDO offer a unified design that allows safe and easy installation in a standard 1" Eldon James port disc, making them ideal for welding to bag stock.
Easy Integration with Dependable Output Signal
The output signal of these single-use pH probes is identical to that of METTLER TOLEDO reusable pH probes, to allow easy integration into existing transmitters and process environments.
Useful Related Links
Differences in Operation Between Analytical Reusable and Single-use Sensors in Bioreactors
In recent years, the deployment of single-use bioreactors (SUBs) has become an important trend in the bioprocessing industry. SUB technology for mammalian cell culture and for microbial cells has achieved major breakthroughs regarding process safety and reliability in order to comply with the industry’s strict requirements. Read more
Technical Data on InSUS Sensor Series
The InSUS™ sensor series for single-use technology bioprocesses cover the measurement parameters pH and dissolved oxygen (DO). These gamma irradiationsterilizable sensors have been designed especially for deployment in stirred single-use bags in the 20 –3,000 L range for applications such as: cell culture, fermentation, virus inactivation, and media/buffer preparation. Read more
Analytical Measurements in Bioreactors: Conventional & Single-use
Trends in biopharmaceutical production and bioprocessing mean that pharmaceutical manufacturers require both flexibility and consistency in their R&D, scale-up and production processes. Analytics play a key role in optimizing yield during scale up, whether in conventional, rigid wall bioreactors or in single-use bags. Read more
High Performance pH and DO Monitoring
Chinese hamster ovary (CHO) cells are favored for use in fermentation processes because of their rapid growth, high protein production, and resistance to most human pathogenic viruses. Read more
Oxygen Theory Guide
Oxygen measurement and control plays an important role in countless processes across the chemical, pharmaceutical, biotechnology, power, and food & beverage industries. Dependable in-line measurement of O2 in liquid and gaseous mixtures is vital for providing continuous, real-time data on oxygen levels. Read more
Process Analytics Product Catalog
The METTLER TOLEDO Process Analytics Catalog provides a comprehensive overview of solutions for analytical measurements in liquid process applications, pure water monitoring and gas-phase measurement. Read more
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FAQs
What is a single-use oxygen sensor?
Single-use oxygen sensors (or single-use dissolved oxygen sensors) are sensors for DO measurement that are designed to be integrated into single-use bags by the bioreactor bag manufacturer. METTLER TOLEDO single-use DO sensors measure the oxygen concentration by an optical measurement principle and can be used in a wide range of bioprocessing applications that require dissolved oxygen measurement inside single-use bags. With their robust design for optimal process safety, METTLER TOLEDO single-use optical DO sensors ensure long-term stability for use throughout an entire batch while offering an output signal identical to that of a reusable sensor. All wetted polymer materials are made of USP 88 VI certified materials.
Can I replace a single-use DO sensor?
Single-use oxygen sensors are directly integrated into the single-use bag (SUB) by the bioreactor bag supplier and cannot be taken out and replaced. The complete SUB assembly with the single-use DO sensor is gamma irradiated and is shipped pre-sterilized to the biopharmaceutical producer. Consequently, integrated single-use oxygen sensors will never be removed from the reactor and will also never be autoclaved.
What METTLER TOLEDO single-use DO sensors are available?
The InSUS 607 by METTLER TOLEDO is a single-use DO sensor designed for integration into single-use bags. This single-use oxygen sensor uses optical technology to provide fast, accurate dissolved oxygen measurements. The shelf life is 36 months dry storage and the disposable DO sensor is made of USP 88 VI certified materials to ensure the highest process safety.
How do I get a METTLER TOLEDO single-use sensor in my bioreactor bags?
METTLER TOLEDO sells single-use sensors directly to bioprocess equipment manufacturers for integration into their single-use devices. These sensors are not directly sold to end users. If you are interested in single-use pH sensors or single-use dissolved oxygen sensors for your manufacturing operation, contact your bioprocess device manufacturer and ask them for METTLER TOLEDO InSUS single-use sensors.